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Anti-RBPMS antibody 豚鼠多抗 | 货号: ER1901-06

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  • 详情
  • 特别提示
  • 评价
  • 产品描述This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.
  • 产品名称Anti-RBPMS antibody
  • 分子量21 kDa
  • 种属反应性Human,Mouse
  • 验证应用WB,ELISA
  • 抗体类型豚鼠多抗
  • 免疫原Synthetic peptide within human RBPMS 1-30 conjugated to Keyhole Limpet Haemocyanin.
  • 偶联Non-conjugated
  • RRIDAB_3069301

  • 性能

  • 形态Liquid
  • 浓度1 mg/ml
  • 存放说明Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型IgG
  • 纯化方式Peptide affinity purified.
  • 亚细胞定位Cytoplasm. Nucleus.
  • 数据链接SwissProt: Q93062 Human
    SwissProt: Q9WVB0 Mouse
  • 其它名称
    • RNA-binding protein with multiple splicing
    • Heart and RRM expressed sequence
    • RBPMS

  • 应用

    ELISA:1:1,000-1:5,000
    WB: 1:500-1:1,000

  • Fig1: Coating Antigens: free peptide
    Coating Concentration: 2 ug/ml, 100ul / well
    Coating Buffer: Phosphate Buffered Saline, pH7.4
    Secondary Antibody: Goat Anti-Guinea pig IgG (H+L), HRP Conjugated(1:1000)

  • 背景文献

  • 1. Teplova M et al. Structural basis underlying CAC RNA recognition by the RRM domain of dimeric RNA-binding protein RBPMS. Q. Rev. Biophys. 2015:1-11 (2015).
    2. Sun Y et al. Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS. Nucleic Acids Res. 34:6314-6326 (2006).
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