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Anti-F4/80 Rat Monoclonal Antibody [4G4] 大鼠单抗 | 货号: RT1212

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  • 特别提示
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  • 产品描述The epidermal growth factor (EGF)-TM7 family constitutes a group of class B G-protein coupled receptors, which includes CD97, EMR1 (EGF-like molecule containing mucin-like hormone receptor 1, designated F4/80 in mouse), EMR2, EMR3, FIRE, and ETL. These family members are characterized by an extended extracellular region with several N-terminal EGF domains, and are predominantly expressed on cells of the immune system. The EGF-TM7 protein family are encoded by a gene cluster on human chromosome 19p13. The F4/80 molecule is solely expressed on the surface of macrophages and serves as a marker for mature macrophage tissues, including Kupffer cells in liver, splenic red pulp macrophages, brain microglia, gut lamina propria, and Langerhans cells in the skin. F4/80/EMR1 undergoes extensive N-linked glycosylation as well as some O-linked glycosylation. The function of F4/80/EMR1 is unclear, but it is speculated to be involved in macrophage adhesion events, cell migration, or as a G-protein coupled signaling component of macrophages.
  • 产品名称Anti-F4/80 Rat Monoclonal Antibody [4G4]
  • 分子量160 kDa
  • 种属反应性Human,Mouse
  • 验证应用WB,IF,IHC-P
  • 抗体类型大鼠单抗
  • 免疫原peptide
  • 偶联Non-conjugated

  • 性能

  • 形态Liquid
  • 浓度1 mg/mL.
  • 存放说明Store at +4℃
  • 存储缓冲液1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
  • 亚型IgG2a
  • 纯化方式Immunogen affinity purified.
  • 亚细胞定位Cell membrane
  • 数据链接Q14246
  • 其它名称
    • ADGRE1 antibody
    • Adhesion G protein coupled receptor E1 antibody
    • Adhesion G protein-coupled receptor E1 antibody
    more

  • 应用

    WB: 1:100-1:1,000
    IF: 1:50-500
    IHC-P: 1:50-500
    FC: 1 μg per 1 x 106 cells

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  • 背景文献

  • 1. Mouline, CC. et al. 2012. Monocytes differentiation upon treatment with a peptide corresponding to the C-terminus of activated T cell-expressed Tirc7 protein. J. Cell. Physiol. 227: 3088-3098.

    2. Zheng, JL. et al. 2012. Cannabinoid receptor type 2 is time-dependently expressed during skin wound healing in mice. Int. J. Legal Med. 126: 807-814.
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