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Anti-IDO Rat Monoclonal Antibody [1G1] 大鼠单抗 | 货号: RT1318

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  • 详情
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  • 评价
  • 产品描述Indoleamine 2,3-dioxygenase (IDO) is an IFN-? inducible enzyme that catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. The gene encoding human IDO maps to chromosome 8p12-p11. IDO, also known as INDO, is an important modulator of immunological responses and protects allogeneic concepti from alloreactive maternal lymphocytes. IDO mediates an interesting inhibitory effect of HeLa cells co-cultured with human PBLs. The ILN-2-induced proliferation response of PBLs is diminished in the presence of HeLa cells while an IDO inhbitor negates this effect. Flow cytometric analysis indicates both mature and immature CD123-positive dentritic cells suppress T cell activity using IDO. IDO-transfected cells co-cultured with T cells reduces T cell proliferation. Additionally, adopted transfer of donor T cells reduces donor T cell numbers in IDO-transgenic mice. The pharmacological or genetic manipulation of IDO may be useful for supressing undesirable T cell response.
  • 产品名称Anti-IDO Rat Monoclonal Antibody [1G1]
  • 分子量42kDa
  • 种属反应性Human,Mouse
  • 验证应用WB,IP,IF,IHC-P
  • 抗体类型大鼠单抗
  • 免疫原Recombinant full length IDO of mouse origin.
  • 偶联Non-conjugated

  • 性能

  • 形态Liquid
  • 浓度1 mg/mL.
  • 存放说明Store at +4℃
  • 存储缓冲液1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
  • 亚型IgG1
  • 纯化方式Protein A affinity purified.
  • 亚细胞定位Cytoplasm
  • 数据链接P14902
  • 其它名称
    • 3-dioxygenase antibody
    • I23O1_HUMAN antibody
    • IDO 1 antibody
    more

  • 应用

    WB: 1:100-1:1,000
    IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
    IF: 1:50-500
    IHC-P: 1:50-500

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  • 背景文献

  • 1. Dobos, N., et al. 2012. The role of indoleamine 2,3-dioxygenase in a mouse model of neuroinflammation-induced depression. J. Alzheimers Dis. 28: 905-915.

    2. Mellor, A.L., et al. 2002. Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses. J. Immunol. 168: 3771-3776.
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