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Anti-MAdCAM-1 Rat Monoclonal Antibody [IgG2a] 大鼠单抗 | 货号: RT1375

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  • 详情
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  • 评价
  • 产品描述The recirculation of lymphocytes through different organs is thought to be regulated by adhesion molecules (“homing receptors”) recognizing tissue-specific vascular addressins on the endothelium. The mucosal vascular addressin, MadCAM-1 (mucosal addressin cell adhesion molecule 1), is an immunoglobulin superfamily adhesion molecule for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into Peyer’s patches and the intestinal lamina propria. MadCAM-1 acts as an endothelial cell ligand for leukocyte homing receptors L-Selectin and Integrin α4/β7. MadCAM-1 is strongly expressed on inflamed portal vein/sinusoidal endothelium in autoimmune-mediated liver disease and plays a major contributory role in the progression of chronic experimental autoimmune encephalomyelitis.
  • 产品名称Anti-MAdCAM-1 Rat Monoclonal Antibody [IgG2a]
  • 分子量40/29 kDa
  • 种属反应性Human,Mouse,Rat
  • 验证应用WB,IP,IF,FC
  • 抗体类型大鼠单抗
  • 免疫原Endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes.
  • 偶联Non-conjugated

  • 性能

  • 形态Liquid
  • 浓度1 mg/ml.
  • 存放说明Store at +4℃.
  • 存储缓冲液1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
  • 亚型IgG2a
  • 纯化方式Immunogen affinity purified.
  • 亚细胞定位Membrane
  • 数据链接SwissProt: Q13477 Human
  • 其它名称
    • Addressin mucosal antibody
    • hMAdCAM 1 antibody
    • hMAdCAM-1 antibody
    more

  • 应用

    WB: 1:100-1:1,000
    IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
    IF: 1:50-1:500
    FC: 1 μg per 1 x 106 cells


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  • 背景文献

  • 1. Grant, A.J., et al. 2001. MAdCAM-1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium (MAdCAM-1 in chronic inflammatory liver disease). Hepatology 33: 1065-1072.

    2. Guilliano, M.J., et al. 2001. The micro-environment of human Peyer’s patches inhibits the increase in CD38 expression associated with the germinal center reaction. J. Immunol. 166: 2179-2185.
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