Mismatch Repair Antibody Sampler Kit 货号: HAK21012-抗体小包装组合-商城-耀元生物医药有限公司

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￥ 4000.00

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产品说明Mismatch Repair Antibody Sampler Kit contains multiple trial-sized versions of anti-human antibody clones against MSH6, PMS2, MLH1, and MSH2, specifically selected for their high performance in multiple applications including IHC. They are provided as a sampler panel to allow you to easily evaluate each in your required application.
产品

产品包括	数量	应用	反应性	MW(kDa)
MLH1[HA721325]	30µl	WB,IHC-P	Human,Rat	Predicted band size: 85 kDa
MSH2[HA601108]	30µl	WB,IF-Cell,IHC-P	Human,Mouse,Rat	Predicted band size: 105 kDa
MSH6[HA721164]	30µl	WB,IHC-P	Human,Mouse	Predicted band size: 153 kDa
PMS2[ET1605-1]	30µl	WB,IF-Cell,IF-Tissue,IHC-P,IP,FC	Human	Predicted band size: 96 kDa

背景
DNA mismatch repair (MMR) proteins are involved in repairing mistakes that occur during DNA replication and recombination, in addition to repairing some types of DNA damage. Defects in the MMR process due to mutations in MMR genes (MSH6, PMS2, MLH1, MSH2) can result in microsatellite instability (MSI), where a DNA sequence accumulates errors and produces abnormally long or shorter microsatellites. These defects in the MMR pathway have been linked to various human cancers, such as human non-polyposis colon cancer (HNPCC) and Muir-Torre Syndrome (MTS), a subtype of HNPCC.
背景文献
1. Modrich, P. (2006) J Biol Chem 281, 30305-9.

2. Kolodner, R.D. and Marsischky, G.T. (1999) Curr Opin Genet Dev 9, 89-96.

3. Pećina-Šlaus, N. et al. (2020) Front Mol Biosci 7, 122.

4. Kok, M. et al. (2019) ESMO Open 4, e000511.

5. Yi, M. et al. (2018) Mol Cancer 17, 129.