Hippo Signaling Antibody Kit 货号: HAK21009-抗体小包装组合-商城-耀元生物医药有限公司

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￥ 4000.00

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产品说明The Hippo Signaling Antibody Sampler Kit provides an economical means of detecting target proteins of the Hippo signaling pathway. The kit contains enough primary antibody to perform two western blots per primary.
产品

产品包括	数量	应用	反应性	MW(kDa)
MOB1A[ER61553]	30µl	WB	Human,Mouse,Rat	23 kDa
YAP1[ET1608-30]	30µl	WB,IF-Cell,IF-Tissue,IHC-P,IP,FC	Human,Rat	Predicted band size: 54 kDa
LATS1/2[ER63847]	30µl	WB,IHC-P,ICC/IF,ELISA	Human,Mouse	130-140 kDa
Mst2[ET1610-8]	30µl	WB,IHC-P,IP	Human,Mouse,Rat	Predicted band size: 56 kDa
MST1[HA500031]	30µl	WB,IHC-P	Human,Mouse	Predicted band size: 57 kDa.
Phospho-YAP1 (S127)[ET1611-69]	30µl	WB,IHC-P	Human,Mouse,Rat	Predicted band size: 54 kDa
TAZ[HA500300]	30µl	WB,IHC-P,IF-Cell	Human,Mouse	44 kDa
HRP Conjugated Goat anti-Rabbit IgG[HA1001]	100µl	WB,ELISA,IHC-P	Rabbit

背景
Hippo signaling is an evolutionarily conserved pathway that controls cell proliferation, apoptosis, and organ size in response to changing cell density levels. At relative low cell density, transcription co-activators YAP and TAZ bind transcription factors to induce expression of genes that favor cell growth and proliferation. As cell density increases, interaction between membrane-bound upstream hippo pathway regulators trigger activation of cytoplasmic kinases Mst1/2 and LATS1/2. Activated Mst kinase (the eponymous Hippo in Drosophila) associates with the adaptor Sav1 and phosphorylates MOB1 to activate LATS kinase, which phosphorylates YAP and TAZ to suppress cell proliferation.
背景文献
1. McNeill, H. and Woodgett, J.R. (2010) Nat Rev Mol Cell Biol 11, 404-13.

2. Zeng, Q. and Hong, W. (2008) Cancer Cell 13, 188-92.

3. Zhao, B. et al. (2007) Genes Dev 21, 2747-61.