Senescence Associated Secretory Phenotype (SASP) Antibody Kit-抗体小包装组合-商城-耀元生物医药有限公司

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￥ 4000.00

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概述
产品说明Senescence Associated Secretory Phenotype (SASP) Antibody Sampler Kit provides an economical means of detecting multiple components of the SASP. The kit includes enough antibody to perform two western blot experiments with each primary antibody.
产品

产品包括	数量	应用	反应性	MW(kDa)
IL-1 beta[ET1701-39]	30µl	WB,IF-Cell,IF-Tissue,IHC-P,FC	Human	Predicted band size: 31 kDa
RANTES[ET1705-70]	30µl	WB,IHC-P,IF-Cell,IF-Tissue	Human,Mouse	Predicted band size: 10 kDa
IP10[ET1704-27]	30µl	WB,IF-Cell,IF-Tissue,IHC-P	Human	11 kDa
PAI1[HA500124]	30µl	WB,IF-Cell,IHC-P	Human,Mouse,Rat	45 kDa
IL-6[EM30301]	30µl	WB,IHC-P	Human	Predicted band size: 24 kDa
TNF alpha[R1203-1]	30µl	WB,ELISA	Mouse	Predicted band size: 26 kDa
MMP3[ET1705-98]	30µl	WB,IHC-P	Human,Mouse,Rat	Predicted band size: 54 kDa
CCL2/MCP1[HA500042]	30µl	WB,IHC-P,IF-Cell	Human	Predicted band size: 11 kDa.
HRP Conjugated Alpaca anti-Rabbit IgG FC, Recombinant VHH[HA1031]	100µl	IP,ELISA,IHC-P,WB	Rabbit
HRP Conjugated Goat anti-Mouse IgG[HA1006]	100µl	WB,ELISA,IHC-P	Mouse

背景
Senescence is characterized by stable stress-induced proliferative arrest and resistance to mitogenic stimuli, as well as the secretion of proteins such as cytokines, growth factors and proteases. These secreted proteins comprise the senescence-associated secretory phenotype (SASP). Senescent cells are thought to accumulate as an organism ages, and contribute to age-related diseases, including cancer, through promotion of inflammation and disruption of normal cellular function. The composition of the SASP varies, and SASP components can be either beneficial or deleterious in human disease, depending on the context. Senescence Associated Secretory Phenotype (SASP) Antibody Sampler Kit provides a collection of antibodies to various SASP components, including TNF-alpha, interleukin-6 (IL-6), the multifunctional cytokine IL-1beta, the chemokines CXCL10, RANTES/CCL5 and MCP-1, the matrix metalloprotease MMP3, and the serine-protease inhibitor PAI-1.
背景文献
1. Tchkonia, T. et al. (2013) J Clin Invest 123, 966-72.

2. Sun, Y. et al. (2018) Trends Mol Med 24, 871-885.

3. Rao, S.G. and Jackson, J.G. (2016) Trends Cancer 2, 676-687.