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Anti-D(1A) dopamine recepr (DRD1) Goat Polyclonal Antibody |

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  • 详情
  • 特别提示
  • 评价
  • 产品描述PAX8 is a transcription factor crucial to the organogenesis and development of the thyroid gland, urogenital tract, placenta and inner ear. In the thyroid, PAX8 is a master gene that regulates maintenance of the differentiated thyroid follicular cell phenotype, where it controls and activates the transcription of the main proteins responsible for the functional activity of follicular cells such as thyroglobulin, thyroperoxidase and sodium/iodide symporter. In the developing kidney PAX8 is important for renal vescicle formation. PAX8 regulates the expression of the WT1 gene. PAX8 appears to be currently the most sensitive and specific marker for renal cell carcinoma and ovarian non-mucinous carcinoma. Follicular and papillary thyroid carcinoma are virually always PAX8 positive (while anaplastic carcinoma is positive in most cases and medullary thyroid carcinoma negative). PAX8 is also found in almost all cases of ovarian serous, endometrioid, transitional and clear cell carcinoma (while mucinous carcinoma is positive in a minor number of cases), and endometrial carcinoma.
  • 产品名称Anti-PAX8 Recombinant Rabbit Monoclonal Antibody [JJ08-88]
  • 分子量Predicted band size: 48 kDa
  • 种属反应性Human
  • 验证应用WB,IF-Cell,IF-Tissue,IHC-P
  • 抗体类型重组兔单抗
  • 免疫原Recombinant protein within Human PAX8 aa 101-450 / 450.
  • 偶联Non-conjugated
  • RRIDAB_3070218

  • 性能

  • 形态Liquid
  • 浓度1 mg/mL.
  • 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型IgG
  • 纯化方式Protein A affinity purified.
  • 亚细胞定位Nucleus.
  • 数据链接SwissProt: Q06710 Human
  • 其它名称
    • OTTHUMP00000158659 antibody
    • OTTHUMP00000158660 antibody
    • OTTHUMP00000203723 antibody
    more

  • 应用

    WB: 1:500-1:2,000
    IF-Cell: 1:50-1:200
    IF-Tissue: 1:50-1:200
    IHC-P: 1:50-1:500


  • 背景文献

  • 1. Wang M et al. PAX2 and PAX8 reliably distinguishes ovarian serous tumors from mucinous tumors. Appl Immunohistochem Mol Morphol 23:280-7 (2015).

    2. Sicking EM et al. Subtotal ablation of parietal epithelial cells induces crescent formation. J Am Soc Nephrol 23:629-40 (2012).
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