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Anti-Cyclin D1 Recombinant Rabbit Monoclonal Antibody [SA38-08]货

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  • 详情
  • 特别提示
  • 评价
  • 产品描述The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDKs (Cyclin-dependent kinase). Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Micrograph of cyclin D1 staining in a mantle cell lymphoma. Immunohistochemical staining of cyclin D1 antibodies is used to diagnose mantle cell lymphoma. Cyclin D1 has been found to be overexpressed in breast carcinoma. Its potential use as a biomarker was suggested.
  • 产品名称Anti-Cyclin D1 Recombinant Rabbit Monoclonal Antibody [SA38-08]
  • 分子量Predicted band size: 34 kDa
  • 种属反应性Human,Mouse,Rat
  • 验证应用WB,IF-Cell,IF-Tissue,IHC-P,IP,FC
  • 抗体类型重组兔单抗
  • 免疫原Synthetic peptide within C-terminal human Cyclin D1.
  • 偶联Non-conjugated
  • RRIDAB_3069614

  • 性能

  • 形态Liquid
  • 浓度1 mg/mL.
  • 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型IgG
  • 纯化方式Protein A affinity purified.
  • 亚细胞定位Cytoplasm, Nucleus, Membrane, Mitochondrion
  • 数据链接SwissProt: P24385 Human
    SwissProt: P25322 Mouse
    SwissProt: P39948 Rat
  • 其它名称
    • AI327039 antibody
    • B cell CLL/lymphoma 1 antibody
    • B cell leukemia 1 antibody
    more

  • 应用

    WB: 1:5,000
    IF-Cell: 1:2,000
    IF-Tissue: 1:50
    IHC-P: 1:50-1:200
    IP: Use at an assay dependent concentration.

    FC: 1:5,000

  • 背景文献

  • 1. Totta, P. et al. 2015. Clathrin heavy chain interacts with estrogen receptor α and modulates 17β-estradiol signaling. Molecular endocrinology (Baltimore, Md.). : me20141385.

    2. Luo, Y. et al. 2015. Lycorine induces programmed necrosis in the multiple myeloma cell line ARH-77. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 36: 2937-45.

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