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Anti-CD204 Recombinant Mouse Monoclonal Antibody [A8G2]

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  • 详情
  • 特别提示
  • 评价
  • 产品描述Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene. MSR1 has also been designated CD204 (cluster of differentiation 204). This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. They were thought to be expressed macrophage-specific, but recently shown to be present on different dendritic cells classes, too. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
  • 产品名称Anti-CD204 Recombinant Mouse Monoclonal Antibody [A8G2]
  • 分子量Predicted band size: 50 kDa
  • 种属反应性Human,Rat
  • 验证应用WB,IHC-P,IF-Cell
  • 抗体类型重组鼠单抗
  • 免疫原Recombinant protein within human CD204 aa 51-250 / 451.
  • 偶联Non-conjugated
  • RRIDAB_3071884

  • 性能

  • 形态Liquid
  • 浓度0.85 mg/mL
  • 存放说明Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • 存储缓冲液PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型IgG1
  • 纯化方式Protein A affinity purified.
  • 亚细胞定位Membrane.
  • 数据链接SwissProt: P21757 Human
    SwissProt: P30204 Mouse
    Entrez Gene: 498638 Rat
  • 其它名称
    • CD204 antibody
    • CD204 antigen antibody
    • CD24 antibody
    more

  • 应用

    WB: 1:1,000
    IHC-P: 1ug/mL-5ug/mL

    IF-Cell: 1:100

  • 背景文献

  • 1. Zhao SJ et al. Macrophage MSR1 promotes BMSC osteogenic differentiation and M2-like polarization by activating PI3K/AKT/GSK3β/β-catenin pathway. Theranostics. 2020 Jan

    2. Gudgeon J et al. The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer. Front Immunol. 2022 Oct

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