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Anti-Beta actin Mouse Monoclonal Antibody [B4-B2]

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  • 详情
  • 特别提示
  • 评价
  • 产品描述Beta-actin (human gene and protein abbreviation ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus. Beta-actin has been shown to interact with SPTBN2. In addition, RNA-binding protein Sam68 was found to interact with the mRNA encoding β-actin, which regulates the synaptic formation of the dendritic spines with its cytoskeletal components. Beta-actin has been shown to activate eNOS, thereby increasing NO production. An eight-amino acid residue (326-333) in actin has been shown to mediate the interaction between actin and eNOS. Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma. Beta actin is often used in Western blotting as a loading control, to normalize total protein amounts and check for eventual protein degradation in the samples. Its transcript is also commonly used as a housekeeping gene standard in qPCR. Its molecular weight is approximately 42 kDa.

  • 产品名称Anti-Beta actin Mouse Monoclonal Antibody [B4-B2]
  • 分子量Predicted band size: 42 kDa
  • 种属反应性Human,Mouse,Rat
  • 验证应用WB,IF-Cell,IHC-P,FC
  • 抗体类型小鼠单抗
  • 免疫原Synthetic peptide within N-terminal of Human beta actin.
  • 偶联Non-conjugated
  • RRIDAB_3073045

  • 性能

  • 形态Liquid
  • 浓度2 mg/mL.
  • 存放说明Store at -20℃. Stable for 12 months from date of receipt.
  • 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • 亚型IgG1
  • 纯化方式Immunogen affinity purified.
  • 亚细胞定位Cytoplasm.
  • 数据链接SwissProt: P60709 Human
    SwissProt: P60710 Mouse
    SwissProt: P60711 Rat
  • 其它名称
    • A26C1A antibody
    • A26C1B antibody
    • ACTB antibody
    more

  • 应用

    WB: 1:1,000-1:10,000
    IF-Cell: 1:100-1:200
    IHC-P: 1:100-1:200
    FC: 1:100-1:200

  • 背景文献

  • 1. "The nucleotide sequence of the rat cytoplasmic beta-actin gene."Nudel U., Zakut R., Shani M., Neuman S., Levy Z., Yaffe D.Nucleic Acids Res. 11:1759-1771(1983)

    2. "De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome."Riviere J.B., Nat. Genet. 44:440-444(2012)
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