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Anti-D(1A) dopamine recepr (DRD1) Goat Polyclonal Antibody

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  • 评价
  • 产品描述The members of the G protein coupled receptor family are distinguished by their slow transmitting response to ligand binding. These transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. -adrenergic receptor binds to adrenaline activates adenylyl cyclase, while 2-adrenergic receptor binds to adrenaline inhibits adenylyl cyclase. The dopamine receptors are divided into two classes, D1 and D2, which differ in their functional characteristics in that D1 receptors stimulate adenylyl cyclase while D2 receptors inhibit adenylyl cyclase activity. Five different subtypes of dopamine receptor have been described to date. D1DR and D5DR belong to the D1 subclass, while D2DR, D3DR and D4DR belong to the D2 subclass.
  • 产品名称Anti-D(1A) dopamine recepr (DRD1) Goat Polyclonal Antibody
  • 分子量74kDa
  • 种属反应性Human,Mouse,Rat
  • 验证应用WB,IP,IF,IHC-P
  • 抗体类型羊多抗
  • 免疫原peptide
  • 偶联Non-conjugated

  • 性能

  • 形态Liquid
  • 浓度1 mg/mL.
  • 存放说明Store at +4℃
  • 存储缓冲液1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
  • 亚型IgG
  • 纯化方式Immunogen affinity purified.
  • 亚细胞定位Cell membrane, Endoplasmic reticulum membrane
  • 数据链接P21728
  • 其它名称
    • D(1A) dopamine receptor antibody
    • D1A dopamine receptor antibody
    • DADR antibody
    more

  • 应用

    WB: 1:100-1:1,000
    IP: 1-2 μg per 100-500 μg of total protein (1 ml of cell lysate)
    IF: 1:50-1:500

    IHC-P: 1:50-1:500

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  • 背景文献

  • 1. Barak, L.S., et al. 1995. The conserved seven-transmembrane sequence NP(X)2,3Y of the G protein-coupled receptor superfamily regulates multiple properties of the β2-adrenergic receptor. Biochem. 34: 15407-15414.

    2. Senogles, S.E. 1994. The D2 dopamine receptor isoforms signal through distinct Gi α proteins to inhibit adenylyl cyclase. A study with site-directed mutant Gi α proteins. J. Biol. Chem. 269: 23120-23127.
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